laura ciapponi

Docente altra Facolta'
BIO/18 ( Genetica )
Altra Facoltà
Dipartimento di Biologia e Biotecnologie, Charles Darwin
Telefono (+39) 06 49912593
Ricevimento

Su appuntamento telefonico (06-49912593) oppure per e-mail Laura.ciapponi@uniroma1.it

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CURRICULUM VITAE ET STUDIORUM
NAME: Laura Ciapponi
PRESENT ADDRESS:                   
“Sapienza” University of Rome
Dept. of Biology and Biotechnologies, C. Darwin
laura.ciapponi@uniroma1.it                                                                  
 
ACADEMIC TRAINING
2008 to dateAssociate Professor at “Sapienza” University of Rome, Department of Biology and Biotechnologies, C. Darwin
2003-2008 Assistant Professor at “Sapienza" University of Rome, Department of Genetics and Molecular Biology, with the “Rientro dei cervelli” program by Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR).
2002 Research fellow at “Sapienza" University of Rome, Department of Genetics and Molecular Biology.
2001 Research associate position at the University of Rochester School of Medicine and Dentistry, Department of Biomedical Genetics (USA, NY).
1998 -2001  Long Term EMBO postdoctoral fellow, EMBL/Heidelberg (Germany), Department of Developmental Biology.
1994-1997  PhD fellow, “Sapienza" University of Rome,Department of Genetics and Molecular Biology/IRBM P. Angeletti-Merck laboratories, Department of Genetics.
1993 Degree in Biology, summa cum laude, at “Sapienza" University of Rome.
 
SCIENTIFIC INTEREST

2002 to date
DNA repair and telomeres stability in Drosophila melanogaster
Genetic control of mitosis in Drosophila melanogaster
Drosophila melanogaster as model of human neurodegenerative disorders

1998-2001
Genetic and biochemical studies of Drosophila transcription factor AP1 as a mediator of different signaling pathways

1996-1997
DNA vaccination and gene therapy studies on interleukin-6 receptor super-antagonists

1993-1995
Investigation of the IL-6 receptor complex properties and generation of interleukin-6 receptor antagonists

1991-1993
Cytokines gene expression
 
Selected Publications
Antonucci L., D’Amico D, Di Magno L., Coni S., Di Marcotullio L., Cardinali B., Gulino A., Ciapponi L. and Canettieri L. CNBP regulates wing development in Drosophila melanogaster by promoting IRES-dependent translation of dMyc. Cell Cycle 2013. 13:434-439. doi: 10.4161/cc.27268.
Raffa G.D., Cenci G., Ciapponi L. and Maurizio Gatti. Organization and evolution of Drosophila telomeres: similarities and differences between Drosophila and human telomeres. Front Oncol. 2013 May 10;3:112. doi: 10.3389/fonc.
Raffa G.D., Ciapponi L., Cenci G., Gatti M. Terminin: A protein complex that mediates epigenetic maintenance of Drosophila telomeres. Nucleus. 2011; 2: 383-391.
Raffa G.D., Raimondo D., Sorino C., Cugusi S., Cenci G., Cacchione S., Gatti M. and Ciapponi L. Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex. Genes & Development 2010; 24: 1596-1601.
Raffa G.D., Siriaco G., Cugusi S., Ciapponi L., Cenci G., Wojcick E. and Gatti M. The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection. PNAS 2009; 106: 2271-2276.
Ciapponi L., Cenci G. Telomere capping and cellular checkpoints: clues from fruit flies. Cytogenet Genome Res. 2008; 122: 365-373.
Somma M.P., Ceprani F., Bucciarelli E., Naim V., De Arcangelis V., Piergentili R., Palena A., Ciapponi L., Giansanti M.G., Pellacani C., Petrucci R, Cenci G., Vernì F., Fasulo B., Goldberg M.L., Di Cunto F. and Gatti M. Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. Plos Genetics 2008; 4(7): e1000126 doi:10.1371/journal.pgen.1000126.
Musarò M., Ciapponi L., Fasulo B., Gatti M. and Cenci G. Unprotected Drosophila telomeres activate the spindle assembly checkpoint. Nature Genetics 2007; 40: 362-366.
Ciapponi L., Cenci G. and Gatti M. The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability. Genetics 2006; 173: 1447-1454.
Cenci G., Ciapponi L. and Gatti M. The mechanism of telomere protection: a comparison between Drosophila and humans. Chromosoma 2005; 114: 135-145.
Ciapponi L., Cenci G., Ducau J., Flores C., Johnson-Schlitz D., Gorski M.M., Engels W.R., Gatti M. Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. Curr Biol. 2004; 14:1360-1366.
Ciapponi L. and Bohmann D. An essential function of AP-1 heterodimers in Drosophila Development. Mechanism of Development 2002; 115: 35-40.
Ciapponi L., Jackson D., Mlozik M., and Bohmann D. Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes & Development 2001; 15: 1540-1553.


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